The human gut microbiome comprises trillions of microbes that have profound effects on many aspects of human health.
Microbial imbalance (dysbiosis) has been associated with conditions like inflammatory bowel disease, obesity, and neurological disorders. Manipulating the gut microbiota through diet, prebiotics, probiotics, synbiotics, antibiotics, fecal transplants, and other interventions is a promising therapeutic approach.
This talk will examine current approaches to modulating the gut microbiota and their potential benefits and limitations. Strategies to be discussed include probiotics, prebiotics, synbiotics, fecal microbiota transplants, antibiotics, and dietary modulation. The mechanisms of action and evidence for each intervention will be reviewed, as well as key knowledge gaps. As our comprehension of the microbiome advances, more refined diagnostic tests and manipulative therapies are likely to emerge. But many unknowns remain regarding optimal techniques to intentionally alter the gut microbiota for specific health benefits.
Careful consideration of current evidence and individual factors is advised when manipulating the microbiome to ensure safe, effective and ethical practice.
Prof Emad El-Omar - The Hidden World Within: Understanding the Human Microbiome
Prof Sunny Wong - The Gut Microbiome Unveiled: How to Manipulate It for Better Health
Prof Nick Talley - Microbes, indigestion, your gut and your brain: searching for the cause(s) and cure
